Pentoxifylline Affects Cytokine Reaction in Cardiopulmonary Bypass


  • Ihsan Iskesen
  • Osman Saribulbul
  • Mustafa Cerrahoglu
  • Ece Onur
  • Bugra Destan
  • Bekir Hayrettin Sirin



Background. Cardiac surgery is associated with an inflammatory response that may cause myocardial dysfunction after cardiopulmonary bypass. We examined the efficacy of pentoxifylline to attenuate the cardiopulmonary bypass-induced inflammatory response during heart operations.

Methods. In a prospective, randomized study, 30 patients undergoing coronary artery bypass graft surgery received either pentoxifylline (group P, n = 15) (continuous infusion of 1.5 mg/kg per hour during operation) or not (group C [control], n = 15). Blood samples for measurements of tumor necrosis factor (TNF)-?, interleukin (IL)-6, IL-8, and IL-10 were taken from the arterial line in both groups at 5 different time points.

Results. TNF-?, IL-6, and IL-8 plasma levels increased in both groups after cardiopulmonary bypass, with a higher increase in the control group (P < .05).

Conclusions. Our results indicate that pentoxifylline infusion during cardiac surgery inhibits the proinflammatory cytokine release caused by cardiopulmonary bypass.


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How to Cite

Iskesen, I., Saribulbul, O., Cerrahoglu, M., Onur, E., Destan, B., & Sirin, B. H. (2006). Pentoxifylline Affects Cytokine Reaction in Cardiopulmonary Bypass. The Heart Surgery Forum, 9(6), E883-E887.