Clinical Observation of Postoperative Warfarin Anticoagulation in 300 Patients Undergoing Mitral Valve Replacement with a Carbomedics Mechanical Valve
DOI:
https://doi.org/10.1532/hsf.1241Abstract
Objective: The objective of this study was to evaluate the safety and efficacy of low-intensity warfarin treatment in Chinese patients after mitral valve replacement as well as the rationality of the INR standards of the hospital (The First People’s Hospital of Jining City).Methods: We retrospectively analyzed 270 cases in our hospital from January 2009 to December 2013; 239 patients completed the 5-year follow-up. There were 192 male and
78 female subjects, age 32-65 years old with a mean age
51.51 ± 12.12 years old. All eligible candidates received a Carbomedics artificial mechanical valve replacement and were anticoagulated under this hospital’s current guidelines for postoperative anticoagulant therapy mitral valve replacement (INR 1.8-2.5). We analyzed the patient’s regularly recorded prothrombin times (PTs) and the occurrence of anticoagulation-related complications, such as bleeding, thrombosis, and embolism.
Results: A follow-up for 239 of 300 patients was performed for 3-60 months. Within this group, one patient died from cerebral hemorrhage, there was 1 case of subcutaneous bleeding, 1 case of epistaxis, 12 cases of gingival bleeding, in 15 menstrual quantity increased, and in 1 case we found cerebral infarction.
Conclusion: In conclusion, low-intensity anticoagulation after mitral Carbomedics valve replacement is therapeutically effective and safe. There is room to improve the anticoagulation standard currently used, perhaps at a slightly lower level than this standard suggests. From our research we can formulate individualized treatment plans and effectively reduce the occurrence of complications.
Published
2015-04-28
How to Cite
Wu, L., Chang, Q., Wang, T., Zhang, Z., & Lou, Y. (2015). Clinical Observation of Postoperative Warfarin Anticoagulation in 300 Patients Undergoing Mitral Valve Replacement with a Carbomedics Mechanical Valve. The Heart Surgery Forum, 18(2), E063-E066. https://doi.org/10.1532/hsf.1241
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