Genetic Variants Associated with Vein Graft Stenosis after Coronary Artery Bypass Grafting

Authors

  • Asad A. Shah Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Duke University Medical Center, North Carolina, NC
  • Carol Haynes Duke Molecular Physiology Institute, Duke University Medical Center, North Carolina, NC
  • Damian M. Craig Duke Molecular Physiology Institute, Duke University Medical Center, North Carolina, NC
  • Jacqueline Sebek Duke Molecular Physiology Institute, Duke University Medical Center, North Carolina, NC
  • Elizabeth Grass Duke Molecular Physiology Institute, Duke University Medical Center, North Carolina, NC
  • Karen Abramson Duke Molecular Physiology Institute, Duke University Medical Center, North Carolina, NC
  • Elizabeth Hauser Duke Molecular Physiology Institute, Duke University Medical Center, North Carolina, NC
  • Simon G. Gregory Duke Molecular Physiology Institute, Duke University Medical Center, North Carolina, NC
  • William E. Kraus 1.Duke Molecular Physiology Institute and 2. Division of Cardiology, Duke University Medical Center, North Carolina, NC
  • Peter K Smith Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Duke University Medical Center, North Carolina, NC
  • Svati H. Shah 1.Duke Molecular Physiology Institute and 2. Division of Cardiology, Duke University Medical Center, North Carolina, NC

DOI:

https://doi.org/10.1532/hsf.1214

Abstract

Background: Vein graft stenosis after coronary artery bypass grafting (CABG) is common. Identifying genes associated with vein graft stenosis after CABG could reveal novel mechanisms of disease and discriminate patients at risk for graft failure. We hypothesized that genome-wide association would identify these genes.
Methods: We performed a genome-wide association study on a subset of patients presenting for cardiac catheterization for concern of ischemic heart disease, who also underwent CABG and subsequent coronary angiography after CABG for clinical indications (n = 521). Cases were defined as individuals with ≥50% stenosis in any vein graft on any cardiac catheterization, and controls were defined as those who did not have vein graft stenosis on any subsequent cardiac catheterization. Multivariable logistic regression was used to assess the association between single nucleotide polymorphisms (SNPs) and vein graft stenosis.
Results: Sixty-nine percent of patients had vein graft failure after CABG. Seven SNPs were significantly associated with vein graft stenosis, including intronic SNPs in the genes PALLD (Rs6854137, P = 3.77 × 10-6), ARID1B (Rs184074,
P = 5.97 × 10-6), and TMEM123 (Rs11225247, P = 8.25 × 10-6); and intergenic SNPs near the genes ABCA13 (Rs10232860, P = 4.54 × 10-6), RMI2 (Rs9921338, P = 6.15 × 10-6), PRM2 (Rs7198849, P = 7.27 × 10-6), and TNFSF4 (Rs17346536,
P = 9.33 × 10-6).
Conclusions: We have identified novel genetic variants that may predispose to risk of vein graft failure after CABG, many within biologically plausible pathways. These polymorphisms merit further investigation, as they could assist in stratifying patients with multi-vessel coronary artery disease, which could lead to alterations in management and revascularization strategy.

Published

2015-04-06

How to Cite

Shah, A. A., Haynes, C., Craig, D. M., Sebek, J., Grass, E., Abramson, K., Hauser, E., Gregory, S. G., Kraus, W. E., Smith, P. K., & Shah, S. H. (2015). Genetic Variants Associated with Vein Graft Stenosis after Coronary Artery Bypass Grafting. The Heart Surgery Forum, 18(1), E001-E005. https://doi.org/10.1532/hsf.1214

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