Intramyocardial CD34<SUP>+</SUP> Cell Transplantation Combined with Off-Pump Coronary Artery Bypass Grafting
AbstractThis report describes a new therapeutic approach for severe ischemic heart disease, intramyocardial transplantation of autologous bone marrow-derived CD34+ cells combined with off-pump coronary artery bypass grafting (CABG). CD34 is widely known as a cell surface antigen expressed on hematopoietic stem cells, and recent experimental studies have shown that CD34+ cells include endothelial progenitor cells. We used the Isolex 300i magnetic cell selection system to separate CD34+ cells from bone marrow cells. This report describes the first case treated with the combination of off-pump CABG and cell transplantation for therapeutic angiogenesis and myocardial regeneration. The transplantation of autologous bone marrow-derived CD34+ cells improved perfusion of the ungraftable ischemic area.
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