Intramyocardial CD34<SUP>+</SUP> Cell Transplantation Combined with Off-Pump Coronary Artery Bypass Grafting

Authors

  • Hiroshi Nagamine
  • Go Watanabe
  • Shintarou Shiobara
  • Hirofumi Takemura
  • Sadahiko Arai
  • Shigeyuki Tomita

DOI:

https://doi.org/10.1532/HSF98.20041018

Abstract

This report describes a new therapeutic approach for severe ischemic heart disease, intramyocardial transplantation of autologous bone marrow-derived CD34+ cells combined with off-pump coronary artery bypass grafting (CABG). CD34 is widely known as a cell surface antigen expressed on hematopoietic stem cells, and recent experimental studies have shown that CD34+ cells include endothelial progenitor cells. We used the Isolex 300i magnetic cell selection system to separate CD34+ cells from bone marrow cells. This report describes the first case treated with the combination of off-pump CABG and cell transplantation for therapeutic angiogenesis and myocardial regeneration. The transplantation of autologous bone marrow-derived CD34+ cells improved perfusion of the ungraftable ischemic area.

References

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Published

2005-01-04

How to Cite

Nagamine, H., Watanabe, G., Shiobara, S., Takemura, H., Arai, S., & Tomita, S. (2005). Intramyocardial CD34<SUP>+</SUP> Cell Transplantation Combined with Off-Pump Coronary Artery Bypass Grafting. The Heart Surgery Forum, 7(4), E285-E287. https://doi.org/10.1532/HSF98.20041018

Issue

Section

Articles