Systems Biology Approaches-based Biomarkers Discovery for Acute Aortic Dissection
Acute aortic dissection (AAD) faces great challenges in early diagnosis and effective drug treatment. Recent developments in systems biology approaches allow high-throughput screening of novel diagnostic biomarkers and potential therapeutic targets. In this review, we summarize the currently available AAD biomarkers identified in the context of genomic, transcriptomic, proteomic, and metabolic profiles, and highlight the benefits of using a combination of these findings for a better understanding of the molecular nature of this life-threatening disease. This review also provides a reference for future studies that employ a comprehensive, multiple-level approach at the single-cell level to decipher the underlying molecular pathophysiology of AAD.
Brownstein AJ, Ziganshin BA, Kuivaniemi H, et al. 2017. Genes Associated with Thoracic Aortic Aneurysm and Dissection: An Update and Clinical Implications. Aorta (Stamford) 5:11-20.
Dong J, Bao J, Feng R, et al. 2017. Circulating microRNAs: a novel potential biomarker for diagnosing acute aortic dissection. Sci Rep 7:12784.
Gu G, Cheng W, Yao C, et al. 2011. Quantitative proteomics analysis by isobaric tags for relative and absolute quantitation identified Lumican as a potential marker for acute aortic dissection. J Biomed Biotechnol 2011:920763.
Guo DC, Grove ML, Prakash SK, et al. 2016. Genetic Variants in LRP1 and ULK4 Are Associated with Acute Aortic Dissections. Am J Hum Genet 99:762-769.
Hannuksela M, Stattin EL, Klar J, et al. 2016. A novel variant in MYLK causes thoracic aortic dissections: genotypic and phenotypic description. BMC Med Genet 17:61.
Isselbacher EM, Lino Cardenas CL, Lindsay ME. 2016. Hereditary Influence in Thoracic Aortic Aneurysm and Dissection. Circulation 133:2516-2528.
Kimura N, Futamura K, Arakawa M, et al. 2017. Gene expression profiling of acute type A aortic dissection combined with in vitro assessment. Eur J Cardiothorac Surg 52:810-817.
LeMaire SA, McDonald ML, Guo DC, et al. 2011. Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1. Nat Genet 43:996-1000.
Mohamed SA, Sievers HH, Hanke T, et al. 2009. Pathway analysis of differentially expressed genes in patients with acute aortic dissection. Biomark Insights 4:81-90.
Nienaber CA, Clough RE. 2015. Management of acute aortic dissection. Lancet 2015 385: 800-811.
Nienaber CA, Clough RE, Sakalihasan N, e al. 2016. Aortic dissection. Nat Rev Dis Primers 2:16071.
Pan S, Lai H, Shen Y, et al. 2017. DNA methylome analysis reveals distinct epigenetic patterns of ascending aortic dissection and bicuspid aortic valve. Cardiovasc Res 113: 692-704.
Pan S, Wu D, Teschendorff AE, et al. 2014. JAK2-centered interactome hotspot identified by an integrative network algorithm in acute Stanford type A aortic dissection. PLoS One 9: e89406.
Pyeritz RE. 2017. Etiology and pathogenesis of the Marfan syndrome: current understanding. Ann Cardiothorac Surg 6: 595-598.
Regalado ES, Guo DC, Villamizar C, et al. 2011. Exome sequencing identifies SMAD3 mutations as a cause of familial thoracic aortic aneurysm and dissection with intracranial and other arterial aneurysms. Circ Res 109: 680-686.
Ren Y, Tang Q, Liu W, et al. 2017. Serum Biomarker Identification by Mass Spectrometry in Acute Aortic Dissection. Cell Physiol Biochem 44:2147-2157.
Ren W, Wang Z, Wu Z, et al. 2017. JAK2/STAT3 Pathway Was Associated with the Protective Effects of IL-22 On Aortic Dissection with Acute Lung Injury. Dis Markers 2017:1917804.
Schachner T, Golderer G, Sarg B, et al. 2010. The amounts of alpha 1 antitrypsin protein are reduced in the vascular wall of the acutely dissected human ascending aorta. Eur J Cardiothorac Surg 37:684-690.
Segreto A, Chiusaroli A, De Salvatore S, et al. 2014. Biomarkers for the diagnosis of aortic dissection. J Card Surg 29: 507-11.
Son BK, Sawaki D, Tomida S, et al. 2015. Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma. Nat Commun 6: 6994.
Suzuki T, Eagle KA. 2018. Biomarker-Assisted Diagnosis of Acute Aortic Dissection. Circulation. 137:270-272.
Wang L, Zhang S, Xu Z, et al. 2017. The diagnostic value of microRNA-4787-5p and microRNA-4306 in patients with acute aortic dissection. Am J Transl Res 9: 5138-5149.
Wang L, Liu S, Yang W, et al. 2017. Plasma Amino Acid Profile in Patients with Aortic Dissection. Sci Rep 7: 40146.
Wang T, He X, Liu X, et al. 2017. Weighted Gene Co-expression Network Analysis Identifies FKBP11 as a Key Regulator in Acute Aortic Dissection through a NF-kB Dependent Pathway. Front Physiol 8:1010.
Wang L, Yao L, Guo D, et al. 2015. Differential expression of microRNAs in aortic tissue and plasma in patients with acute aortic dissection. J Geriatr Cardiol 12: 655-661.
Wang Y. 2012. Gene expression profiling in acute Stanford type B aortic dissection. Vasc Endovascular Surg 46: 300-309.
Weis-Müller BT, Modlich O, Drobinskaya I, et al. 2006. Gene expression in acute Stanford type A dissection: a comparative microarray study. J Transl Med 4: 29.
Xiao Z, Xue Y, Yao C, et al. 2016. Acute Aortic Dissection Biomarkers Identified Using Isobaric Tags for Relative and Absolute Quantitation. Biomed Res Int 2016: 6421451.
Xu Z, Wang Q, Pan J, et al. 2017. Characterization of serum miRNAs as molecular biomarkers for acute Stanford type A aortic dissection diagnosis. Sci Rep 7: 13659.
Zhang K, Pan X, Zheng J, et al. 2015. Comparative tissue proteomics analysis of thoracic aortic dissection with hypertension using the iTRAQ technique. Eur J Cardiothorac Surg 47: 431-438.
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